Paricalcitol (chemically it is
19-nor-1,25-(OH)2-vitamin D2. Marketed by Abbott Laboratories beneath the
barter name Zemplar) is a biologic acclimated for the blockage and analysis of
accessory hyperparathyroidism (excessive beard of parathyroid hormone)
associated with abiding renal failure. It is an analog of
1,25-dihydroxyergocalciferol, the alive anatomy of vitamin D2 (ergocalciferol).
Paricalcitol is a constructed noncalcemic,
nonphosphatemic vitamin D analogue. Paricalcitol binds to the vitamin D
receptor and has been apparent to abate parathyroid hormone (PTH) levels. This
abettor aswell increases the announcement of PTEN ('Phosphatase and Tensin
homolog deleted on chromosome Ten'), a tumor-suppressor gene, in leukemic beef
and cyclin-dependent kinase inhibitors, consistent in bump corpuscle apoptosis
and bump corpuscle adverse into accustomed phenotypes.
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