Parthenolide
may be accessible in cancer, leukemia and cephalalgia headache. It aswell has
anti-inflammatory and anti-tumor properties.
Naunyn
Schmiedebergs Arch Pharmacol. 2016. Accustomed compounds for pediatric blight
treatment. This analysis will abode the "status of the art"
accompanying to the abeyant of accustomed compounds that are ability analysis
in aggregate with accepted ameliorative protocols in preclinical and analytic
studies and their accent for pediatric blight treatment. The aboriginal studies
of biologic analysis of these accustomed compounds discussed actuality cover
the capital targets, the cellular signaling pathways involved, and the abeyant
modes of action. We aswell focus on some able accustomed compounds that accept
apparent accomplished after-effects in vitro and in vivo: Chebulagic acid, Apigenin,
Norcantharidin, Saffron/Crocin, Parthenolide, Longikaurin E, Lupeol,
Spongistatin 1, and Deoxy-variolin B.
Drug
Analysis Today. 2013. Parthenolide: from plant shoots to blight roots.
Parthenolide, a sesquiterpene lactone (SL) originally antiseptic from the
shoots of feverfew (Tanacetum parthenium), has apparent almighty anticancer and
anti-inflammatory activities. It is currently getting activated in blight
analytic trials. Structure-activity accord (SAR) studies of parthenolide appear
key actinic backdrop appropriate for biological activities and epigenetic
mechanisms, and led to the derivatization of an orally bioavailable analog,
dimethylamino-parthenolide (DMAPT). Parthenolide is the aboriginal baby atom
begin to be careful adjoin blight axis beef (CSC), which it achieves by
targeting specific signaling pathways and killing blight from its roots.
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