what is Tacrolimus

Tacrolimus is FK506, is extracted from a soil fungus macrolide antibiotic, has strong immunosuppressive
properties, is the strength of its drug cyclosporin A, 10-100 times, arise prevention of organ
transplant rejection is better than cyclosporine.
 Tacrolimus is only applied to the clinical history of more than ten years, the time is shorter.
Therefore, in some respects (Pharmacology and Toxicology) study is not comprehensive enough. The main
side effects of Tacrolimus nephrotoxicity, neurotoxicity, and circulatory system, digestive system,
respiratory system and cardiovascular system function. Tacrolimus can induce diabetes (odds of about 10%
to 30%), can cause severe ketoacidosis. Tacrolimus-related incidence of hypertension than CsA
significantly reduced. Tacrolimus and CsA with rapamycin compared with rapamycin is a calmodulin does
not interact with the new immunosuppressive agents, is considered to have no effect on blood pressure.
 Immunosuppressant macrolides (including FK506 and rapamycin, etc.) not only orally, but also for
external use, mainly for some skin diseases such as atopic dermatitis, psoriasis, lichen planus, contact
dermatitis and bald spots, etc. have a certain effect. In addition, "Arthritis and Rheumatism" magazine
(Arthritis Rheum 2003; 48:3328-3337) 12, says a report released last month, immunosuppressant tacrolimus
in 2 or 3mg / day dose of a single treatment of active rheumatoid arthritis (RA) appears safe and
effective, but usually larger doses greater improvements.
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