Lonidamine Description

CAS No.:50264-69-2

Molecular Formula:C15H10Cl2N2O2

Molecular Weight:321.16

Lonidamine is an indazole compound that has been appear to arrest angiogenic-related endothelial corpuscle functions. This compound has been begin to activate apoptosis in endothelial beef and could cause a abatement in proliferation, migration, invasion, and morphogenesis. The apoptotic furnishings of Lonidamine accept been approved to be due to Bax, Bid, caspase-3, and caspase-9 activation, as able-bodied as cytochrome c release. Futher studies appearance that Lonidamine prevents cellular activity metabolism via HXK (hexokinase) inhibition.

Lonidamine, originally articular as a almighty antispermatogenic agent, inhibits glycolysis admitting the inactivation of mitochondria-bound hexokinase. It can abatement oxygen burning as able-bodied as aerobic and anaerobic glycolysis in Ehrlich ascites bump beef with IC50 ethics of 90 and 45 µM, respectively. A role for lonidamine as a ameliorative for mitochondrial dysfunction has been explored in assorted disorders, including cancer, neurodegenerative and neuromuscular diseases, obesity, and diabetes.