Pharmacology - Like chloramphenicol, florfenicol is a ample spectrum antibacterial that has action adjoin abounding bacteria. It acts by bounden to the 50S ribosome, thereby inhibiting bacterial protein synthesis.
Uses/Indications - The biologic is accustomed for use in beasts alone (in the
Because florfenicol has action adjoin a advanced ambit of microorganisms (e.g., Mycoplasma), it may be advantageous for alleviative added infections in beasts (or added species) as well, but specific abstracts acknowledging these uses is anon lacking.
Pharmacokinetics - After IM injection, about 79% of the dosage is bioavailable. The biologic appears to be able-bodied broadcast throughout the body, including accomplishment of ameliorative levels in the CSF. In cattle, alone about 13% is apprenticed to serum proteins. Mean serum bisected action is 18 hours, but advanced interpatient aberration exists.
Drug Interactions - No specific biologic interactions for florfenicol were located, but the biologic may behave analogously to chloramphenicol. If so, florfenicol could alienate the bactericidal action of the penicillins or aminoglycosides. This animosity has not been approved in vivo, and these biologic combinations accept been acclimated auspiciously abounding times clinically. Added antibiotics that bind to the 50S ribosomal subunit of affected bacilli (erythromycin, clindamycin, lincomycin, tylosin, etc.) may potentially alienate the action of chloramphenicol or carnality versa, but the analytic acceptation of this abeyant alternation has not been determined. For added biologic interactions that florfenicol may allotment with chloramphenicol, see that album or accredit to added biologic advice resources.
more about:
Aspartame properties and use
Adverse reactions and side effects of aspartame
The Aspartame Information
from:
biochemical reagent
没有评论:
发表评论