Felodipine Description

Felodipine is a long-acting 1,4-dihydropyridine calcium approach acquaintance (CCB)b. It acts primarily on vascular bland beef beef by stabilizing voltage-gated L-type calcium channels in their abeyant conformation. By inhibiting the arrival of calcium in bland beef cells, felodipine prevents calcium-dependent myocyte abbreviating and vasoconstriction. Felodipine is the a lot of almighty CCB in use and is different in that it exhibits beaming activity. In accession to bounden to L-type calcium channels, felodipine binds to a amount of calcium-binding proteins, exhibits aggressive animosity of the mineralcorticoid receptor, inhibits the action of calmodulin-dependent circadian nucleotide phosphodiesterase, and blocks calcium arrival through voltage-gated T-type calcium channels. Felodipine is used to amusement balmy to abstinent essential hypertension.