General Information of Tetracyclines

Tetracycline is a broad-spectrum antimicrobial which has a absolute but blah activity abut the asexual claret stages of all plasmodial species. It is aswell animate abut the primary intrahepatic stages of P. falciparum. The anxiously accompanying substances doxycycline and minocycline allocation its actions.

Absorption of tetracycline from the gut is consistently abridged and can be added torn by acid substances and chelating agents and, particularly, by milk and milk products, and by aluminium, calcium, magnesium and determined salts.

Peak claret concentrations activity aural 4 hours and admixture with a half-life of about 8 hours. Excretion is able primarily by glomerular filtration into the urine. Enterohepatic agreement gives dispatch to top concentrations in the alarmist and bile.

Tetracyclines bad-tempered the placenta and are excreted into breast milk.