Description of Gossypol (CAS 303-45-7)

Synonym:                         Pogosin; AT101; 2,2'-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene)

CAS Number:                      303-45-7

Purity:                          ≥90%

Molecular Weight:                518.56

Molecular Formula:               C30H30O8

Solubility:                      Soluble in 100%ethanol (25 mg/ml), DMF (25 mg/ml), acetone, DMSO (25 mM), methanol (2 mg/ml), ether, chloroform, sodium carbonate, and dilute aqueous solutions of ammonia . Insoluble in water.

Melting Point:                   198° C

Boiling Point:                   707.89° C at 760 mmHg

Density:                         1.40 g/cm3

Application:                     An inhibitor of PKC, Bcl-2, 5-LO, and 12-LO

Storage:                         Store at -20° C

Description:

Gossypol is a male antifertility agent with antispermatogenic activity and has been shown to contain antitumor, anitviral, and antioxidant properties. Gossypol is a reversible inhibitor of PP2B (protein phosphatase 2B), mitotic kinesin Eg5, and PKC (protein kinase C). Gossypol also potentially inhibits PAF-R, Bcl-2, 5-LO (5-lipoxygenase), 12-LO, and leukotriene-induced guinea pig parenchyma contractions. Gossypol is an inhibitor of Bcl-xl, PKD and p107.